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Studies of Inhaled Drugs

Inhaled Drugs

Several inhaled drug formulations were studied by radiolabeling the active ingredient (several different steriods) with C-11 or F-18, formulating that ingredient as the dosage form (different MDI, DPI, and nebulizer formulations), and performing quantitative PET studies of the regional biodistribution and kinetics.
Click on images to see additional examples, larger versions, and videos.

A change in excipients in the formulation produced a striking change in distribution and kinetics.
Another subject, and display graphic method, in the excipient change study.
The use of a spacer caused a highly statistically significant change in distribution in a study with an N of only four.
A comparison of one identical pulmonary inhalation formulation with use of a spacer(left) and no spacer (right).
A single subject, PET/MRI overlay, showing 3D Image of inhaled drug in the lungs.
Comparison of PET 3D Image and typical planar scintigraphy 2D Image.
A nasal image and the anatomic goal of nasally delivered drugs for allergic rhinitis.
3D rendering of a nasally administered C-11 steroid drug.
Distributions of drugs after nasal inhalation.
A comparison of two similar formulations of similar drugs in a crossover study.
Different subjects in a nasal drug deposition study (monochrome MRI overlaid on color PET).
 Different subjects in a nasal drug deposition study (monochrome MRI overlaid on color PET).
Three dimensional regions of interest used for analysis of nasal distribution studies.
Nasal distribution kinetics of two different drugs in a single subject (time lapse video).
Single subject nasal inhalation, distribution kinetics (time lapse video).
A second submect, nasal inhalation time lapse video.
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Little Rock, Arkansas 72205
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